Expresión de búsqueda: RNA-INDUCED SILENCING COMPLEX 
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Descriptor Inglés:   RNA-Induced Silencing Complex 
Descriptor Español:   Complejo Silenciador Inducido por ARN 
Descriptor Portugués:   Complexo de Inativação Induzido por RNA 
Sinónimos Inglés:   RISC Multicomponent Nuclease
Complex, RNA-Induced Silencing
Multicomponent Nuclease, RISC
Nuclease, RISC Multicomponent
RNA Induced Silencing Complex
Silencing Complex, RNA-Induced  
Categoría:   D08.811.277.352.355.350.810
D08.811.277.352.700.350.810
D12.776.157.725.500.906
D12.776.664.962.500.906
Definición Inglés:   A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA). 
Relacionados Inglés:   RNA Interference
RNA, Small Interfering
 
Nota Histórica Inglés:   2003; use RNA-INDUCED SILENCING COMPLEX (NM) 2001-2002 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   37323 
Identificador Único:   D034743 

Ocurrencia en la BVS:
 

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